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The MHRA will continue to monitor reports and provide further updates should they be required. The wellness-warrior’s ally of choice, the perennially Instagrammable seed is the definition of “superfood”. With potassium, zinc, iron and magnesium all contributing to testosterone production, fertility and muscle growth, sprinkle on top of your morning oats to start your day with a T-boost.

  • Adverse drug reactions reported to the MHRA are looked at and used to assess the balance of risks and benefits of medicines and vaccines.
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Steroids of varying potency were used by the patients commonest being Betamethasone Valerate (72.8%) followed by use of topical combination of Clobetasole Propionate, anti-biotics and anti-fungals (18.4%). The mean duration of use of TC was 2 months (68%) which ranged from 1 day to 15 years. Out of 250 patients 241 patients misused in terms of duration (more than the required duration) summarized in [Table/Fig-2]. Of 142 social media blogs on topical steroid withdrawal reactions, 26 were blogs discussing children, the majority of these (18) were from the USA, with 4 being from the UK.

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People with atopic dermatitis are thought to be most at risk of developing topical steroid withdrawal reactions (Hajar and others, 2015). We identified 55 reports in the Yellow Card database that are probable reports of topical steroid withdrawal reactions and 62 further reported reactions potentially indicative of topical steroid withdrawal reactions. The authors’ literature search yielded no studies on or reporting classic topical steroid withdrawal reactions in children. However, periorificial dermatitis, which is generally a steroid-induced disorder in children, was reported in more than 320 cases.

  • However, if used very often or continually for a prolonged time, there have been reports of withdrawal reactions after they are stopped.
  • Because of the possible risk in stressful conditions, a corticosteroid ID should be made for patients undergoing long-term treatment.
  • The table below is reported as the common features of topical steroid withdrawal reactions.
  • Tuberculous meningitis only in conjunction with anti-infective therapy.

They reported that the papulopustular withdrawal subtype is more likely in patients who develop steroid rosacea, but this is not a prerequisite condition for this subtype. The papulopustular variant can be differentiated from the erythematoedematous subtype by the prominent features of pustules and papules, along with erythema, but less frequently swelling, oedema, burning, and stinging. If a corticosteroid is used on the skin, this is known as a topical corticosteroid. These may come in the form of creams, ointments, lotions, mousses, shampoos, gels or tapes.


Each 5 ml of oral solution contains 2 mg dexamethasone as dexamethasone sodium phosphate. A dictionary of international medical terminology used by regulatory authorities and medical organisations. A United Kingdom pharmaceutical reference containing information and advice on prescribing and pharmacology of medicines.

A particularly severe type of topical steroid withdrawal reaction has been reported with skin redness (or a spectrum of colour changes or change in normal skin tone) and burning worse than the original condition. Even though the current product information for topical corticosteroids may list some of the individual symptoms of topical steroid withdrawal reactions, there is no mention of reactions occurring after cessation of treatment. The cases have been reported over a wide time-period, and the majority of reports are from patients.

This is because of the quick symptomatic relief of many skin disorders by the application of TC in the first instance. This can develop confidence in patient a little longer with a general physician or specialists other than dermatologist. There is also a tendency to re-use old prescription for a new rash or lesion. Friends and relatives also share the same prescription presuming that similar looking skin problems can be self-treated by simply copying the old prescription is quite rampant.

Appendix D. Topical corticosteroids for the treatment of atopic eczema, grouped by potency

Before the start of corticosteroid treatment, hypokalemia should be corrected and patients should be monitored clinically, for electrolytes and by electrocardiography. Furthermore, there are case reports in which the simultaneous use of amphotericin the best legal steroids B and hydrocortisone led to an enlarged heart and heart failure. In such patients, the plasma concentrations of dexamethasone may be higher and its excretion slower than in younger patients, therefore its dose should be reduced accordingly.

The Medicines and Healthcare products Regulatory Agency (MHRA) is the government agency responsible for regulating medicines and medical devices in the UK. We continually review the safety of all medicines in the UK and inform healthcare professionals and the public of the latest updates. The Commission on Human Medicines (CHM) advises government ministers and the MHRA on the safety, efficacy and quality of medicines. Examples of topical corticosteroid medicines include beclometasone, betamethasone, clobetasol, hydrocortisone, mometasone, and triamcinolone.

About topical steroid withdrawal reactions

We found fungal infection (38%) was the most common reason of abuse followed by facial acne (29%) and lightening of skin colour (8.4%). Friends and family (33.2%) were found to be the most influencing factors for misuse of TC. Betamethasone (72.8%) was the most commonly used TC preparation and tinea incognito (26.4%) followed by facial acne (25.6%) were the most common side effect experienced. These adverse events are experienced by patients shortly after stopping treatment, with a rebound of the original eczema that then spreads further.